For patients with malignant pleural mesothelioma that has grown despite treatment with standard chemotherapy, no treatment has yet proven beneficial. The purpose of this study is to find out what effects, both good and bad, that everolimus has on the cancer. Everolimus works by blocking a protein that helps the cancer grow. The goal of this clinical research study is to learn if the study drug everolimus can shrink or slow the growth of mesothelioma. The safety of this drug will also be studied. The patients’ physical state, changes in the size of the tumor, and laboratory findings taken during the study will help us decide if everolimus is safe and effective.

In April 2009, the Asian Asbestos Conference (AAC 2009) was held in Hong Kong. This landmark event accelerated the ban asbestos debate in China, the world’s largest asbestos user. New contacts were made and conduits developed with campaigners working in China on issues relating to occupational and environmental health. As a result of the discussions and demonstrations held in Hon Kong, the Asian Ban Asbestos Network (A-BAN) was formed.

Drug developer Bionomics Ltd plans to conduct a Phase II clinical trial of its leading compound, anti-cancer drug BNC105, on 60 Mesothelioma patients in Australia next year.

According to the American Journal of Industrial Medicine, DOE construction workers have an increased risk of certain cancers. In fact, the most significant finding at Hanford was a very high rate of mesothelioma, a cancer of the protective lining that covers most of the body’s internal organs.

Researchers from the North Carolina State University, The Hamner Institutes for Health Sciences, and the National Institute of Environmental Health Sciences used a mouse model to examine the effect of inhalation of multi-walled carbon nanotubes on the lungs.

Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic company, today announced the nationwide commercial launch of three new cancer diagnostic products: ProOnc TumorSourceDx, ProOnc SquamousDx and ProOnc MesotheliomaDx. Each of these tests is based on recently developed, highly sensitive microRNA technology.

Purpose: Malignant pleural mesotheliomas (MPMs) are tumours associated with asbestos exposure involving the tissue lining surrounding the lung. Radiation therapy (RT) dramatically reduces the risk of tumour recurrence within the irradiated area (>90%). But patients continue to succumb to MPMs due to the tumour spreading outside the chest cavity. This may be due to tumour cells inadvertently contaminating areas outside the chest cavity during surgery. The study will look at whether giving a short intense course of chest radiation just prior to surgery will sterilized these tumour cells and thus, avoid or reduce contamination of the areas outside the chest cavity. The investigators hypothesize that short neoadjuvant (pre-operative) hemithoracic RT, followed by immediate planned extrapleural pneumonectomy (EPP) (+/- adjuvant chemotherapy) will reduce the risk of intra-operative seeding and reduce the incidence of distant metastatic disease.

PINEHURST – The FirstHealth of the Carolinas Clinical Trials Department has partnered with the Wake Forest School of Medicine to promote participation in a research study investigating the development and progression of asbestos-related lung diseases and cancers.

Before she dies, Dorothy Kuykendall wants her day in court. The 76-year-old from Terre Haute was exposed to asbestos, a toxin that can lead to a deadly cancer called mesothelioma, more than three decades ago when she handled the material regularly as a worker at the city’s Glas-Col Apparatus Co.

Despite the best surgical efforts, complete removal of mesothelioma is possible in approximately 30% of the patients. When surgical removal is complete, chemotherapy followed by radiation therapy is recommended as an effort to improve control over the cancer and survival. This combination of treatments is called TRIMODALITY therapy. Unfortunately, the chances for the tumor coming back after TRIMODALITY therapy remains high. When surgical removal is not complete or not possible, some patients may receive chemo and/or radiation therapy to achieve control over the cancer, but the chances of tumor to growth again remains high and the chances of long term survival remains low.