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Mesothelioma Articles

PTK787/ZK 222584 in Treating Patients With Unresectable Malignant Mesothelioma

This study is currently recruiting patients

Sponsored by

National Cancer Institute (NCI)

Alternate Title

Phase II Study of PTK787/ZK 222584 in Patients With Unresectable Malignant Mesothelioma

Purpose

PTK787/ZK 222584 may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth.

Phase II trial to study the effectiveness of PTK787/ZK 222584 in treating patients with unresectable malignant mesothelioma.

Eligibility:

   •   At least 19 years old

   •   Measurable disease

   •   No brain metastases

   •   No previous chemotherapy for this cancer

   •   At least 4 weeks since radiation therapy

   •   At least 2 weeks since surgery

   •   No previous PTK787/ZK 222584

Final eligibility for a clinical trial is determined by the health professionals conducting the trial. For more details about the eligibility requirements for this trial and the treatment or intervention, refer to the Health Professional version of the trial summary at the National Cancer Institute (NCI)

Treatment/Intervention:

Patients will receive PTK787/ZK 222584 by mouth once a day for as long as benefit is shown. Patients will be evaluated every 2 months for 1 year, every 4 months for 1 year, and every 6 months for 1 year.

Important:

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Cancer and Leukemia Group B
Thierry Jahan, MD, Protocol chair
Ph: 415-353-7105; 800-888-8664

Trial Sites and Contacts

U.S.A.

Delaware
Newark
CCOP - Christiana Care Health Services
Stephen Grubbs, MD
Ph: 908-685-2200

District of Columbia
District of Columbia
Lombardi Cancer Center at Georgetown University Medical Center
Edward Gelmann, MD
Ph: 202-444-7303
Email: gelmanne@georgetown.edu

Veterans Affairs Medical Center - Washington, DC
Steven Krasnow, MD
Ph: 202-745-8178
Email: krasnow.steven@washington.va.gov

Walter Reed Army Medical Center
Thomas Reid, MD, PhD, FACP
Ph: 202-782-6751

Maryland
Baltimore
Herbert Irving Comprehensive Cancer Center at Columbia University
Martin Edelman, MD
Ph: 410-328-2703
Email: medelman@umm.edu

Massachusetts
Boston
Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
George Canellos, MD
Ph: 617-632-3470
Email: george_canellos@dfci.harvard.edu

Worcester
University of Massachusetts Memorial Medical Center - University Campus
Pankai Bhargava
Ph: 508-856-6884
Email: bhargavp@ummhc.org

New Hampshire
Hooksett
New Hampshire Oncology-Hematology, PA - Hooksett
Douglas Weckstein, MD
Ph: 603-622-6484
Email: d.weckstein@nhoh.com

Lebanon
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center
Marc Stuart Ernstoff, MD
Ph: 603-650-5534, 1-800-639-6918
Email: Marc.S.Ernstoff@Hitchcock.org

New Jersey
Camden
Cooper University Hospital
Edison Catalano, MD
Ph: 856-342-2506, 1-800-8-COOPER

New York
East Syracuse
CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
Jeffrey Kirshner, MD
Ph: 315-472-7504

Elmhurst
Elmhurst Hospital Center
Vladimir Benisovich, MD
Ph: 718-334-3723
Email: beniso@aol.com

Jamaica
Queens Cancer Center of Queens Hospital
Hans Grunwald, MD
Ph: 718-883-4118
Email: hans.grunwald@mssm.edu

Manhasset
CCOP - North Shore University Hospital
Vincent Vinciguerra, MD
Ph: 516-562-8954

North Shore University Hospital
Daniel Budman, MD
Ph: 516-562-8958

New York
Memorial Sloan-Kettering Cancer Center
Clifford Hudis, MD
Ph: 212-639-6483

Mount Sinai Medical Center, NY
Lewis Silverman, MD
Ph: 212-241-5520
Email: lewis.silverman@mssm.edu

New York Weill Cornell Cancer Center at Cornell University
Scott Wadler, MD
Ph: 212-746-2844

Syracuse
University Hospital at State University of New York - Upstate Medical University
Stephen Graziano, MD
Ph: 315-464-8200, 877-464-8668
Email: grazians@upstate.edu

North Carolina
Goldsboro
CCOP - Southeast Cancer Control Consortium
James Atkins, MD
Ph: 919-580-0000

Kinston
Lenoir Memorial Hospital Cancer Center
Peter Watson, MD
Ph: 919-559-2200 Ext. 201

Rhode Island
Providence
Lifespan: The Miriam Hospital
William Sikov, MD
Ph: 401-793-7151
Email: wsikov@lifespan.org

Vermont
Burlington
Vermont Cancer Center at University of Vermont
Hyman Muss, MD
Ph: 802-847-3827

Virginia
Norfolk
Virginia Oncology Associates - Norfolk
Paul Conkling, MD
Ph: 757-466-8683

Richmond
MBCCOP - Massey Cancer Center
John Roberts, MD
Ph: 804-828-0450

Source: National Cancer Institute

***Please note that the clinical trials listed on this page have additional specific requirements. Call contacts listed for each trial for more detailed information.