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Mesothelioma Articles
Phase II Study of Alanosine in Patients With Methylthioadenosine Phosphorylase (MTAP)-Deficient Cancer
Date First Published: 2003-05-23
BASIC STUDY INFORMATION
| Type of Trial |
Status of Trial |
Age Range (yrs.) |
Sponsor of Trial |
Protocol IDs |
| Treatment |
Active |
18 and over (13 and over for osteosarcoma only) |
NCI, Pharmaceutical/Industry |
MSKCC-03029, SALMEDIX-SDX-102-01 |
PATIENT ABSTRACT:
Rationale:
Drugs used in chemotherapy such as alanosine use different ways to stop tumor cells from dividing so they stop growing or die.
Purpose:
Phase II trial to study the effectiveness of alanosine in treating patients who have soft tissue sarcoma, sarcoma of the bone, mesothelioma, non-small cell lung cancer, or pancreatic cancer.
Eligibility:
•At least 18 years old (at least 13 years old for patients who have osteosarcoma)
•Measurable disease
•More than 6 weeks since chemotherapy
•At least 4 weeks since radiation therapy to the brain
•At least 4 weeks since surgery
Treatment Intervention:
Patients will receive a 5-day continuous infusion of alanosine every 3 weeks. Treatment may be repeated for up to nine courses. Patients will be evaluated at 4 weeks.
Disclaimer:
This abstract is intended to give a brief overview of this clinical trial. To help determine whether the trial is appropriate for an individual, selected major eligibility criteria are listed above. To obtain more details related to trial eligibility and the treatment plan, please see the Health Professional abstract of this clinical trial. Information about ongoing clinical trials is available from the NCI Cancer.gov Web site.
STUDY LEAD ORGANIZATIONS:
Memorial Sloan-Kettering Cancer Center
Lee M. Krug, MD, Protocol chair
Ph: 212-639-8420
STUDY SITES AND CONTACTS
U.S.A.
New York
Memorial Sloan-Kettering Cancer Center
Lee M. Krug, MD
Ph: 212-639-8420
St. Vincents Comprehensive Cancer Center
Gerald Rosen, MD
Ph: 212-367-1729
gerald.rosen@verizon.net
Source: Cancer.gov
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